From Mechanical Forces to Tissue Straining – How Biophysical Cues Can Be Used to Guide Regeneration


Thursday, March 14, 2019, 4:30pm to 5:30pm


60 Oxford Street, Room 330

Conceptually, our research aims at understanding endogenous cascades of tissue formation, cytokine signaling and cellular self-organization especially in bone. Mechanical straining and adaptation due to mechanical cues plays a central role in all these tissues. The aim of our work is to understand the mechano-biological cues of regeneration and adaptation and how they can be employed to enable healing even in tissues with impaired regenerative capacity such as muscle, cartilage or tendon. All approaches are motivated by clinical challenges, are based on in vivo patient measurements, employ basic research principles and aim at being translated into daily clinical routine. Examples of translation include innovative concepts for joint replacement procedures, angle stable fixation of implants or cell therapies for muscle regeneration.

Speaker Bio
Georg Duda is Professor of Biomechanics and Musculoskeletal Regeneration at the Charité – Humboldt University of Berlin and Free University of Berlin and an Associated Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University. He received his Master’s degree in precision engineering from the Technical University of Berlin, Germany, in 1991 and his Ph.D. degree in Mechanical Engineering from the Technical University of Hamburg-Harburg in 1996. He co-chairs the Berlin Regenerative Research Center including an associated graduate school.