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  • 2020 Dec 10

    Cole DeForest, University of Washington

    12:00pm

    Location: 

    Zoom

    User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate

    Guest Speaker: Cole DeForest, University of Washington

    Abstract: The extracellular matrix directs stem cell function through a complex choreography of biomacromolecular interactions in a tissue-dependent manner. Far from static, this hierarchical milieu of biochemical and biophysical cues presented within the native cellular niche is both spatially complex and ever changing. As these pericellular reconfigurations are vital for tissue morphogenesis, disease...

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  • 2020 Nov 19

    David Fairén-Jiménez, University of Cambridge

    10:00am

    Location: 

    Zoom

    Materials discovery and molecular engineering of porous materials 

    David Fairen-Jimenez

    The Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK.

     

    The building-block approach to the synthesis of metal-organic frameworks (MOFs) has opened the possibility to synthesise a virtually infinite number of these materials. This creates exciting opportunities, but also raise the question of how to identify and classify MOFs...

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  • 2020 Nov 05

    Elizabeth Wayne, Carnegie Mellon University

    12:00pm

    Location: 

    Zoom

    Macrophage Engineering: Biomaterials to modulate macrophage polarization for drug delivery and diagnostics

    Most modern drug formulations are encapsulated within nanoparticles, biomaterials, or protein conjugations.  Macrophages are among the first cells to interact with these therapeutic materials making them prime candidates for observation. It was largely believed that this was an obstacle, that macrophages phagocytose these therapies and inhibit the overall efficacy. However, newly available information, suggests that macrophages can act as slow release...

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  • 2020 Oct 29

    Stephanie Lacour, EPFL

    12:00pm

    Location: 

    Zoom

    Soft Designs for Electrode Systems that Communicate with the Nervous System

    Stéphanie P. Lacour
    EPFL Laboratory for Soft Bioelectronic Interfaces
    Center for Neuroprosthetics

     

    In the past decade, developments in materials science, electronics and biology have opened pathways to novel and precise communication with biological tissues.  Several of these new designs are being deployed for neuroscience research; some advance towards medical research and therapy. 

    The design, manufacturing and implementation of...

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  • 2020 Oct 22

    Betty Kim, MD Anderson Cancer Center

    12:00pm

    Location: 

    Zoom

    Targeting Phagocytosis for Cancer Immunotherapy

    Guest Speaker: Betty Kim, Associate Professor, Department of Neurosurgery, University of Texas MD Anderson Cancer Center

    Abstract: Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment- refractory cancer types. However, emerging studies have demonstrated that innate immune checkpoints, which interfere with the detection and clearance of malignant cells through phagocytosis and suppress innate...

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  • 2020 Oct 15

    Lola Eniola-Adefeso, University of Michigan

    12:00pm

    Location: 

    Zoom

    Understanding Cellular-Particle Interactions in Blood: Implications for Disease Pathology and Treatment

    Lola Eniola-Adefeso
    Professor and Miller Faculty Scholar, University of Michigan

    Localized delivery of therapeutics offers the possibility of increased drug effectiveness while minimizing side effects often associated with systemic drug administration.  Factors that influence the likelihood of targeted particle therapeutics to reach the vascular wall are the ability to identify: 1) a disease-specific target, 2) the...

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  • 2020 Oct 08

    Ian Wong, Brown University

    12:00pm

    Location: 

    Zoom

    Beyond 2D: Collective Cell Migration and Topological Data Analysis

    Ian Y. Wong
    Assistant Professor of Engineering and Medical Science, Brown University

    Epithelial cells transition between collective and individual migration during development and disease, analogous to interacting building blocks (dis)assembling as an active material. In this seminar, I will present recent results on my group to investigate so-called epithelial-mesenchymal transitions in the context of soft matter physics, mechanobiology, and machine learning....

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  • 2020 Oct 01

    Sarah Heilshorn, Stanford

    12:00pm

    Location: 

    Zoom (registration required)

    Protein Engineering of Multi-functional Biomaterials for Regenerative Medicine

    Sarah Heilshorn
    Professor of Materials Science & Engineering, Stanford University

    Stem cell transplantation is a promising therapy for a myriad of debilitating diseases and injuries; however, current expansion and transplantation protocols are inadequate. My lab designs biomaterials to overcome these challenges using biomimetic, protein-engineering technology. By integrating protein science methodologies with simple polymer physics models, we manipulate the...

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